I-Astaxanthin Synthesis ku-Chlamydomonas Reinhardtii

I-PROTOGA isanda kumemezela ukuthi ihlanganise ngempumelelo i-astaxanthin yemvelo e-Chlamydomonas Reinhardtii nge-Microalgae Genetic Modification Platform, futhi manje ithuthukisa ubuhlakani obuhlobene nocwaningo kanye nocwaningo lokucubungula. Kubikwa ukuthi lesi yisizukulwane sesibili samaseli onjiniyela abekwe epayipini le-astaxanthin futhi azoqhubeka nokuphindaphinda. Isizukulwane sokuqala samaseli onjiniyela sesingene esigabeni sokuhlola. Ukuhlanganiswa kwe-astaxanthin ku-Chlamydomonas Reinhardtii yokukhiqizwa kwezimboni kungaba phezulu ngezindleko, ukukhiqiza kanye nekhwalithi kunaleyo ye-Haematococcus Pluvialis.

I-Astaxanthin iyi-xanthophyll yemvelo neyokwenziwa kanye ne-nonprovitamin A carotenoid, enemisebenzi engaba yi-antioxidant, elwa nokuvuvukala kanye ne-antioplastic. Umsebenzi wayo we-antioxidant izikhathi ezingu-6000 kune-vitamin C kanye nezikhathi ezingu-550 kune-vitamin E. I-Astaxanthin inokusebenza okuhle kakhulu ekulawuleni amasosha omzimba, ukugcinwa kwesistimu yenhliziyo, impilo yamehlo nobuchopho, amandla esikhumba, ukulwa nokuguga nezinye izinhlelo zokusebenza. I-Astaxanthin ivame ukusetshenziswa emikhiqizweni yokunakekelwa kwezempilo, imikhiqizo yokudla okunomsoco enomphumela wokunakekelwa kwezempilo futhi yengezwe kuzimonyo ezinomphumela we-antioxidant.

Imakethe yomhlaba wonke ye-astaxanthin kulindeleke ukuthi ifinyelele ku- $ 2.55 billion ngo-2025 ngokusho kweGrand View Research. Njengamanje, umsebenzi we-astaxanthin otholwe ku-chemical synthesis kanye ne-Phaffia rhodozyma uphansi kakhulu kunalowo ovela ku-levo-astaxanthin yemvelo etholakala ku-microalgae ngenxa yomsebenzi wayo wesakhiwo. Yonke i-levo-astaxanthin yemvelo emakethe ivela ku-Haematococcus Pluvialis. Kodwa-ke, ngenxa yokukhula kwayo kancane, umjikelezo omude wamasiko futhi kulula ukuthintwa yizici zemvelo, amandla okukhiqiza e-Haematococcus Pluvialis anomkhawulo.

Njengomthombo omusha wemikhiqizo yemvelo kanye neseli ye-chassis ye-synthetic biology, i-microalgae inenethiwekhi ye-metabolic eyinkimbinkimbi kanye nezinzuzo ze-biosynthesis. I-Chlamydomonas Reinhardtii i-chassis yephethini, eyaziwa ngokuthi "imvubelo eluhlaza". I-PROTOGA yaba yingcweti kubuchwepheshe bokuhlela i-microalgae ethuthukisiwe kanye nobuchwepheshe bokuvutshelwa kwe-microalgae engezansi. Ngesikhathi esifanayo, i-PROTOGA ithuthukisa ubuchwepheshe be-photoautotrophic .Uma ubuchwepheshe bokuzalanisa sebuvuthiwe futhi bungasetshenziswa ekukhiqizeni isikali, buzophakamisa ukusebenza kahle kokuhlanganiswa kokuguqula i-CO2 emikhiqizweni esekelwe ku-bio.