Ukufunyanwa kweMicroalgae Extracellular Vesicles

I-extracellular vesicles i-endogenous nano-size vesicles efihliweyo ngamaseli, ukusuka kwi-30-200 nm ububanzi obugqunywe kwi-lipid bilayer membrane, ephethe i-nucleic acids, iiprotheni, i-lipids kunye ne-metabolites, njl njl. ezibandakanyekayo kutshintshiselwano lwemathiriyeli phakathi kweeseli. I-extracellular vesicles inokufihlwa ngeendidi zeeseli phantsi kweemeko eziqhelekileyo kunye neemeko ze-pathological, eziphuma ikakhulu kwi-polyvesicles ezenziwe ngamaqhekeza e-intracellular lysosomal kwaye zikhutshwe kwi-matrix ye-extracellular emva kokuhlanganiswa kwe-membrane ye-extracellular kunye ne-cell membrane ye-polyvesicles. Ngenxa ye-immunogenicity ephantsi, imiphumo emibi engeyiyo inetyhefu, ukujoliswa okunamandla, amandla okuwela umqobo wegazi-ubuchopho kunye nezinye iimpawu, kuye kwathathwa njengomphathi weziyobisi. Kwi-2013, iBhaso leNobel kwiPhysiology kunye neMedicine lanikezelwa kwiinzululwazi ezintathu ezinxulumene nokufundwa kwee-vesicles zangaphandle. Ukusukela ngoko, izangqa zezemfundo kunye nezoshishino ziye zaqalisa ukunyuka kwe-extracellular vesicles uphando kunye nophuhliso, ukusetyenziswa kunye nokuthengisa.

Ii-vesicles ze-Extracellular ezivela kwiiseli zezityalo zizityebi kwizinto ezisebenzayo ezizodwa, ezincinci ngobukhulu kwaye zikwazi ukungena kwizicubu. Uninzi lwazo lunokuthatyathwa kwaye lufakwe ngokuthe ngqo emathunjini. Ngokomzekelo, i-ginseng vesicles inceda ekuhlukaniseni iiseli ze-stem kwiiseli ze-nerve, kwaye i-ginger vesicles inokulawula i-intestinal flora kunye nokunciphisa i-colitis. IMicroalgae zezona zityalo zindala zineseli enye emhlabeni. Kukho malunga ne-300,000 yeentlobo ze-microalgae ezisasazwe ngokubanzi kwiilwandle, amachibi, imilambo, iintlango, amathafa, ama-glaciers kunye nezinye iindawo, ezineempawu ezizodwa zengingqi. Ngexesha lokuvela kwe-3 yebhiliyoni yoMhlaba, i-microalgae ibisoloko ikwazi ukukhula njengeeseli enye emhlabeni, engenakuhlukaniswa nokukhula okungaqhelekanga kunye nokukwazi ukuzilungisa.

I-Microalgal extracellular vesicles zizinto ezintsha ezisebenzayo ze-biomedical ezinokhuseleko oluphezulu kunye nokuzinza. I-Microalgae ineenzuzo ezininzi ekuveliseni i-extracellular vesicles, njengenkqubo yenkcubeko elula, elawulwayo, ephantsi, ekhula ngokukhawuleza, ukukhutshwa okuphezulu kwee-vesicles kunye nokulula ukwenza ubunjineli. Kwizifundo zangaphambili, i-microalgal extracellular vesicles ifunyenwe ukuba ifakwe lula ngaphakathi ngeeseli. Kwiimodeli zezilwanyana, zafunyaniswa ukuba zifakwe ngokuthe ngqo ngamathumbu kwaye ziphuculwe kwizicubu ezithile. Emva kokungena kwi-cytoplasm, inokuhlala iintsuku ezininzi, ehambelana nokukhululwa kweziyobisi ixesha elide.

Ukongezelela, i-microalgal extracellular vesicles kulindeleke ukuba ilayishe iindidi zamachiza, eziphucula ukuzinza kweeamolekyu, ukukhululwa okucothayo, ukuguquguquka komlomo, njl., ukuxazulula imiqobo ekhoyo yokulawula iziyobisi. Ke ngoko, uphuhliso lwe-microalgae extracellular vesicles lunokwenzeka kakhulu kwinguqu yeklinikhi kunye noshishino.