Kupezeka kwa Microalgae Extracellular Vesicles

Ma vesicles a extracellular ndi ma nano-size vesicles omwe amapangidwa ndi maselo, kuyambira 30-200 nm m'mimba mwake atakulungidwa mu membrane ya lipid bilayer, yomwe imakhala ndi nucleic acid, mapuloteni, lipids ndi metabolites, ndi zina zotero. zomwe zimakhudzidwa ndi kusinthana kwa zinthu pakati pa maselo. Ma vesicles owonjezera amatha kutulutsidwa ndi ma cell osiyanasiyana pansi pazikhalidwe zabwinobwino komanso za pathological, zomwe makamaka zimachokera ku ma polyvesicles opangidwa ndi ma lysosomal particles ndipo amamasulidwa ku matrix a extracellular pambuyo kuphatikizika kwa nembanemba ya extracellular ndi cell nembanemba ya polyvesicles. Chifukwa cha kuchepa kwake kwa chitetezo chamthupi, zotsatira zake zopanda poizoni, kulunjika mwamphamvu, mphamvu yodutsa chotchinga chamagazi-muubongo ndi zina, zimawonedwa ngati zotengera mankhwala. Mu 2013, Mphotho ya Nobel mu Physiology and Medicine idaperekedwa kwa asayansi atatu okhudzana ndi kafukufuku wa ma vesicles akunja. Kuyambira pamenepo, mabwalo amaphunziro ndi mafakitale ayambitsa kuchuluka kwa kafukufuku ndi chitukuko cha ma extracellular vesicles, kugwiritsa ntchito ndi kugulitsa.

Ma vesicles a extracellular kuchokera ku maselo a zomera ali ndi zigawo zogwira ntchito zapadera, zazing'ono mu kukula kwake komanso amatha kulowa mu minofu. Ambiri aiwo amatha kutengedwa ndikulowetsedwa mwachindunji m'matumbo. Mwachitsanzo, ma ginseng vesicles amathandizira kusiyanitsa kwa maselo a tsinde kukhala ma cell a minyewa, ndipo ma vesicles a ginger amatha kuwongolera matumbo am'mimba ndikuchepetsa kutupa. Microalgae ndi zomera zakale kwambiri za cell imodzi padziko lapansi. Pali mitundu pafupifupi 300,000 ya algae yomwe imagawidwa kwambiri m'nyanja, nyanja, mitsinje, zipululu, mapiri, madzi oundana ndi malo ena, okhala ndi mawonekedwe apadera achigawo. Pachisinthiko cha 3 biliyoni Padziko Lapansi, ma microalgae akhala akuyenda bwino ngati maselo amodzi Padziko Lapansi, omwe sangasiyanitsidwe ndi kukula kwawo modabwitsa komanso kudzikonza okha.

Ma Microalgal extracellular vesicles ndi zida zatsopano zogwirira ntchito zokhala ndi chitetezo chokwanira komanso kukhazikika. Ma Microalgae ali ndi maubwino angapo pakupanga ma vesicles owonjezera, monga njira yosavuta yachikhalidwe, kuwongolera, kutsika mtengo, kukula mwachangu, kutulutsa kwakukulu kwa ma vesicles komanso kosavuta kupanga. M'maphunziro am'mbuyomu, ma microalgal extracellular vesicles adapezeka kuti amalowetsedwa mosavuta ndi maselo. M'zitsanzo za nyama, adapezeka kuti amalowetsedwa mwachindunji kudzera m'matumbo ndikulemeretsedwa muzinthu zinazake. Pambuyo polowa mu cytoplasm, imatha masiku angapo, zomwe zimathandiza kuti mankhwala atulutsidwe kwa nthawi yayitali.

Kuphatikiza apo, ma microalgal extracellular vesicles akuyembekezeka kunyamula mankhwala osiyanasiyana, omwe amathandizira kukhazikika kwa mamolekyu, kutulutsa pang'onopang'ono, kusinthasintha kwapakamwa, ndi zina zambiri, kuthetsa zopinga zomwe zilipo kale. Choncho, chitukuko cha microalgae extracellular vesicles ali ndi kuthekera mkulu mu matenda kusintha ndi mafakitale.