Nchọpụta nke Microalgae Extracellular Vesicles

Extracellular vesicles bụ endogenous nano-size vesicles secreted site sel, sitere na si 30-200 nm ke dayameta enveloped na a lipid bilayer akpụkpọ anụ, nke na-ebu nucleic acid, protein, lipids na metabolites, wdg Extracellular vesicles bụ isi ngwaọrụ nke intercellular nkwurịta okwu. nke na-etinye aka na mgbanwe nke ihe n'etiti sel. Enwere ike izobe vesicles dị iche iche site na mkpụrụ ndụ dị iche iche n'okpuru ọnọdụ nkịtị na nke pathological, nke na-esite na polyvesicles nke a na-emepụta site na intracellular lysosomal particles ma na-ahapụ ya n'ime matrix extracellular mgbe ngwakọta nke akpụkpọ anụ extracellular na akpụkpọ ahụ sel nke polyvesicles. N'ihi obere immunogenicity ya, mmetụta ndị na-adịghị egbu egbu, ebumnuche siri ike, ikike ịgafe mgbochi ụbụrụ ọbara na njirimara ndị ọzọ, a na-ewere ya dị ka onye nwere ike ibu ọgwụ. N'afọ 2013, e nyere ndị ọkà mmụta sayensị atọ ihe nrite Nobel na Physiology and Medicine metụtara ọmụmụ nke vesicles dị n'èzí. Kemgbe ahụ, ngalaba agụmakwụkwọ na ụlọ ọrụ ewepụtala mmụba nke nyocha na mmepe nke vesicles extracellular, ngwa na azụmaahịa.

Extracellular vesicles sitere na mkpụrụ ndụ ihe ọkụkụ bara ụba na ihe pụrụ iche na-arụ ọrụ, obere nha ma nwee ike ịbanye n'ime anụ ahụ. Enwere ike iwere ọtụtụ n'ime ha wee banye ozugbo n'ime eriri afọ. Dịka ọmụmaatụ, ginseng vesicles na-eme ka ọdịiche nke mkpụrụ ndụ sel n'ime mkpụrụ ndụ akwara, na ginger vesicles nwere ike ịhazi flora intestinal ma belata colitis. Microalgae bụ osisi nwere otu mkpụrụ ndụ kacha ochie n'ụwa. Enwere ihe fọrọ nke nta ka ọ bụrụ ụdị microalgae 300,000 na-ekesa n'oké osimiri, ọdọ mmiri, osimiri, ọzara, mbara ala, glaciers na ebe ndị ọzọ, nwere njirimara mpaghara pụrụ iche. N'oge evolushọn nke ijeri ụwa 3, microalgae enweela ike itolite mgbe niile dị ka otu mkpụrụ ndụ n'ụwa, nke na-enweghị ikewapụ ya na uto ha pụrụ iche na ike imezi onwe ha.

Microalgal extracellular vesicles bụ ihe ọhụrụ na-arụ ọrụ biomedical nwere nchekwa na nkwụsi ike dị elu. Microalgae nwere ọtụtụ uru na mmepụta nke extracellular vesicles, dị ka usoro omenala dị mfe, njikwa, ọnụ ala, ngwa ngwa ngwa ngwa, mmepụta dị elu nke vesicles ma dị mfe ịmepụta. N'ime ọmụmụ ihe gara aga, achọpụtara na sel microalgal extracellular vesicles na-abanye n'ime ya ngwa ngwa. N'ụdị anụmanụ, achọpụtara na ha na-etinye aka ozugbo site na eriri afọ ma mee ka ha baa ọgaranya n'ụdị anụ ahụ. Mgbe ịbanye na cytoplasm, ọ nwere ike ịdịgide ruo ọtụtụ ụbọchị, nke na-enyere aka ịhapụ ọgwụ na-adịte aka.

Tụkwasị na nke ahụ, a na-atụ anya na microalgal extracellular vesicles ga-ebu ọgwụ dị iche iche, nke na-eme ka nkwụsi ike nke ụmụ irighiri ihe, ntọhapụ ngwa ngwa, ngbanwe ọnụ, wdg, na-edozi ihe mgbochi nchịkwa ọgwụ dị ugbu a. Ya mere, mmepe nke microalgae extracellular vesicles nwere nnukwu ohere na mgbanwe ụlọ ọgwụ na mmepụta ihe.